32247-96-4
- Product Name：3,5-Bis(Trifluoromethyl)Benzyl Bromide
- MF：C9H5BrF6
- Purity：99%
- Molecular Weight：307.033
Product Details
Good factory exports good 3,5-Bis(Trifluoromethyl)Benzyl Bromide 32247-96-4
- Molecular Formula:C9H5BrF6
- Molecular Weight:307.033
- Appearance/Colour:colorless to yellow brown Clear liquid
- Vapor Pressure:1.34mmHg at 25°C
- Melting Point:18°C
- Refractive Index:n20/D 1.445(lit.)
- Boiling Point:178.3 °C at 760 mmHg
- Flash Point:26.1 °C
- PSA：0.00000
- Density:1.651 g/cm3
- LogP:4.61910
3,5-Bis(trifluoromethyl)benzyl bromide(Cas 32247-96-4) Usage
|
Synthesis |
Synthesis of 3, 5-bis (trifluoromethyl)-benzyl bromide:In a 4-neck flask with capacity 1000 ml equipped with mechanical agitator, thermometer, bubble condenser and 100 ml loading funnel, 262.2 g of the product of Example 1 (ii) at 92. 8% (0. 988 moles), 550,2 g HBr 48% (3.2645 moles) are loaded; this is heated at 50°C so as to melt the alcohol, then one starts to dose 113 g of concentrated His04 (1.153 moles). Pouring is accomplished in 30 minutes, noting an increase of the internal temperature. This is heated to 100-105°C and left to react for 8 hours. The reaction is completed by reflux heating for per 1.5 hours. the mixture is left to settle and the phases are separated; the solvents are removed from the organic phase and the product in the title is obtained with a yield of 99.1 %. |
InChI:InChI=1/C9H5BrF6/c10-4-5-1-6(8(11,12)13)3-7(2-5)9(14,15)16/h1-3H,4H2
32247-96-4 Relevant articles
One-Step Synthesis of Substituted Benzofurans from ortho- Alkenylphenols via Palladium-Catalyzed C=H Functionalization
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PROCESS FOR THE PREPARATION 3,5-BIS(TRIFLUOROMETHYL)BENZYLALCOHOL
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32247-96-4 Process route
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32707-89-4
3,5-bis(trifluoromethyl)benzenemethanol
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32247-96-4
3,5-bis(trifluoromethyl)benzyl bromide
| Conditions | Yield |
|---|---|
|
With
sulfuric acid; hydrogen bromide;
In
water;
at 50 - 105 ℃;
for 10h;
Heating / reflux;
|
99.1% |
|
With
phosphorus tribromide;
In
dichloromethane;
for 0.5h;
Cooling with ice;
|
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32247-96-4
3,5-bis(trifluoromethyl)benzyl bromide
| Conditions | Yield |
|---|---|
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32247-96-4 Upstream products
-
32707-89-4
3,5-bis(trifluoromethyl)benzenemethanol
32247-96-4 Downstream products
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2-(3,5-Bis-trifluoromethyl-benzyloxy)-1,1,2,2-tetrafluoro-ethanesulfonyl fluoride
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754-41-6
2-(fluorosulfonyl)tetrafluoropropionyl fluoride
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132130-92-8
1-(3,5-Bis-trifluoromethyl-benzyloxy)-1,1,2,3,3,3-hexafluoro-propane-2-sulfonyl fluoride
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169673-06-7
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