85068-33-3
- Product Name：3,5- Bis(Trifluoromethyl)Phenylacetic Acid
- MF：C10H6F6O2
- Purity：99%
- Molecular Weight：272.147
Product Details
Good factory supply good 3,5- Bis(Trifluoromethyl)Phenylacetic Acid 85068-33-3
- Molecular Formula:C10H6F6O2
- Molecular Weight:272.147
- Appearance/Colour:white to beige powder
- Vapor Pressure:0.0432mmHg at 25°C
- Melting Point:121-123 °C(lit.)
- Boiling Point:227.7 °C at 760 mmHg
- PKA:3.99±0.10(Predicted)
- Flash Point:91.5 °C
- Density:1.479 g/cm3
3,5-Bis(trifluoromethyl)phenylacetic acid(Cas 85068-33-3) Usage
InChI:InChI=1/C10H6F6O2/c11-9(12,13)6-1-5(3-8(17)18)2-7(4-6)10(14,15)16/h1-2,4H,3H2,(H,17,18)/p-1
85068-33-3 Relevant articles
Visible-Light-Enabled Carboxylation of Benzyl Alcohol Derivatives with CO2 Using a Palladium/Iridium Dual Catalyst
Iwasawa, Nobuharu,Jin, Yushu,Toriumi, Naoyuki
, (2021/12/14)
A highly efficient carboxylation of benz...
Development of Novel Mitochondrial Pyruvate Carrier Inhibitors to Treat Hair Loss
Liu, Xiaoguang,Flores, Aimee A.,Situ, Lisa,Gu, Wen,Ding, Hui,Christofk, Heather R.,Lowry, William E.,Jung, Michael E.
, p. 2046 - 2063 (2021/02/16)
Herein, we report the synthesis and eval...
Oxidation of Alkynyl Boronates to Carboxylic Acids, Esters, and Amides
Li, Chenchen,Li, Ruoling,Zhang, Bing,Zhao, Pei,Zhao, Wanxiang
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A general efficient protocol was develop...
COMPOSITIONS AND METHODS FOR MODULATING HAIR GROWTH
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Page/Page column 82-83, (2020/07/21)
The present disclosure relates to compou...
85068-33-3 Process route
-
-
328-70-1
3,6-bis(trifluoromethyl)bromobenzene
-
-
108-59-8
malonic acid dimethyl ester
-
-
85068-33-3
3,5-bistrifluoromethylphenyl acetic acid
| Conditions | Yield |
|---|---|
|
malonic acid dimethyl ester;
With
sodium methylate;
In
1,2-dimethoxyethane;
at 69 - 74 ℃;
copper(l) iodide; copper(I) bromide;
In
1,2-dimethoxyethane;
at 54 ℃;
Heating / reflux;
3,6-bis(trifluoromethyl)bromobenzene;
With
sodium hydroxide;
copper(l) iodide; copper(I) bromide;
more than 3 stages;
|
89% |
-
-
85068-32-2
3,5-bis(trifluoromethyl)phenylacetonitrile
-
-
85068-33-3
3,5-bistrifluoromethylphenyl acetic acid
| Conditions | Yield |
|---|---|
|
With
potassium hydroxide;
In
ethylene glycol;
at 135 ℃;
for 12h;
Sealed tube;
Large scale;
|
2.42 kg |
85068-33-3 Upstream products
-
725-89-3
3,5-bistrifluoromethylbenzoic acid
-
785-56-8
3,5-bis(trifluoromethyl)phenyl carboxylic acid chloride
-
328-70-1
3,6-bis(trifluoromethyl)bromobenzene
-
95299-16-4
methyl [3,5-bis(trifluoromethyl)-phenyl]-acetate
85068-33-3 Downstream products
-
95299-16-4
methyl [3,5-bis(trifluoromethyl)-phenyl]-acetate
-
174083-39-7
2-(3,5-bis(trifluoromethyl)phenyl)acetyl chloride
-
180623-48-7
N-(3,4-dimethoxyphenethyl)-3,5-bis-trifluoromethylphenylacetamide
-
374791-09-0
N-(4-Oxo-1-phenylcyclohexyl)-3,5-bis(trifluoromethyl)benzeneacetamide
Relevant Products
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3,5-Bis(Trifluoromethyl)Benzoyl ChlorideCAS：785-56-8
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